Freezing of gait and fall detection in Parkinson’s disease using wearable sensors:a systematic review

Despite the large number of studies that have investigated the use of wearable sensors to detect gait disturbances such as Freezing of gait (FOG) and falls, there is little consensus regarding appropriate methodologies for how to optimally apply such devices. Here, an overview of the use of wearable systems to assess FOG and falls in Parkinson’s disease (PD) and validation performance is presented. A systematic search in the PubMed and Web of Science databases was performed using a group of concept key words. The final search was performed in January 2017, and articles were selected based upon a set of eligibility criteria. In total, 27 articles were selected. Of those, 23 related to FOG and 4 to falls. FOG studies were performed in either laboratory or home settings, with sample sizes ranging from 1 PD up to 48 PD presenting Hoehn and Yahr stage from 2 to 4. The shin was the most common sensor location and accelerometer was the most frequently used sensor type. Validity measures ranged from 73–100% for sensitivity and 67–100% for specificity. Falls and fall risk studies were all home-based, including samples sizes of 1 PD up to 107 PD, mostly using one sensor containing accelerometers, worn at various body locations. Despite the promising validation initiatives reported in these studies, they were all performed in relatively small sample sizes, and there was a significant variability in outcomes measured and results reported. Given these limitations, the validation of sensor-derived assessments of PD features would benefit from more focused research efforts, increased collaboration among researchers, aligning data collection protocols, and sharing data sets

A Hybrid approach for biomedical relation extraction using finite state automata and random forest-weighted fusion

Comunicació presentada a: The 18th International Conference on Computational Linguistics and Intelligent Text Processing (CICLing 2017), celebrada a Budapest, Hungria, del 17 al 23 d'abril de 2017.The automatic extraction of relations between medical entities found in related texts is considered to be a very important task, due to the multitude of applications that it can support, from question answering systems to the devel-opment of medical ontologies. Many different methodologies have been pre-sented and applied to this task over the years. Of particular interest are hybrid approaches, in which different techniques are combined in order to improve the individual performance of either one of them. In this study, we extend a previ-ously established hybrid framework for medical relation extraction, which we modify by enhancing the pattern-based part of the framework and by applying a more sophisticated weighting method. Most notably, we replace the use of regu-lar expressions with finite state automata for the pattern-building part, while the fusion part is replaced by a weighting strategy that is based on the operational capabilities of the Random Forests algorithm. The experimental results indicate the superiority of the proposed approach against the aforementioned well-established hybrid methodology and other state-of-the-art approaches.This work was supported by the project KRISTINA (H2020-645012), funded by the European Commission. Deidentified clinical records used in this research were provided by the i2b2 National Center for Biomedical Computing funded by U54LM008748 and were originally prepared for the Shared Tasks for Challenges in NLP for Clinical Data organized by Dr. Ozlem Uzuner, i2b2 and SUNY

Can the Current Mobile Technology Help for Medical Assistance? The Case of Freezing of Gait in Parkinson Disease

Parkinson’s disease (PD) affects around 1.5 % people aged 65 years. Among PD features, freezing of gait (FOG) is frequent, involving 70 % PD people after 10 years of disease onset, and highly disabling. Effective management of FOG is a challenge for the limited responsiveness to both drug treatment and functional neurosurgery. As “cueing on demand” is the only strategy of proven efficacy on FOG, it would be crucial to develop a portable assistive device able to release suitable cues at every time the FOG occurs during the daily living (DL) of the patient, without interfering with his/her daily activities. The current smart mobile telephony devices are in principle apt to satisfy all the above mentioned requisites in terms of technological feasibility of ambulation monitoring devices and in terms of acceptability, because of their increasing widespread diffusion. In this paper we will outline a smart-phone based architecture able to detect FOG, to produce the proper cues, and to provide information for continuous monitoring of the events. The paper will specifically consider the clinical necessity, technical feasibility, economic sustainability of the solution proposed and its potential of application